• Bupivacaine-loaded chitosan hydrogels for topical anesthesia in dentistry 

  Mihalache, Cristian; Rață, Delia-Mihaela; Cadinoiu, Anca-Niculina; Patraș, Xenia; Șindilar, Eusebiu-Viorel; Băcăiță, Simona-Elena; Popa, Marcel; Atanase, Leonard-Ionuț; Darabă, Oana-Maria (Wiley, 2020-05-31)

  The paper describes the preparation of polymeric hydrogels, loaded with bupivacaine, which could represent a good alternative in clinical dentistry as local anesthetics. The hydrogels were prepared by condensation using ...
• Antifungal Potential of Pimpinella Anisum, Carum Carvi and Coriandrum Sativum Extracts. A Comparative Study With Focus on the Phenolic Composition 

  Trifan, Adriana; Bostănaru, Andra-Cristina; Luca, Simon-Vlad; Grădinaru, Adina-Catinca; Jităreanu, Alexandra; Aprotosoaie, Ana-Clara; Miron, Anca; Cioancă, Ana; Hăncianu, Monica; Ochiuz, Lăcrămioara; Bujor, Alexandra; Aelenei, Petruța; Mareș, Mihai (Romanian Society for Pharmaceutical Sciences, 2020)

  The present study aimed to characterize the phenolic extracts obtained from fruits of Pimpinella anisum L., Carum carvi L. and Coriandrum sativum L. (Apiaceae), and to assess their antifungal activity against main etiological ...
• Synthesis and Characterization of Inclusion Complex of Diminazene Aceturate with b-Ciclodextrin 

  Lupu, Andrei-Cristian; Bomboș, Mihaela; Vasilievici, Gabriel; Miron, Liviu-Dan (Revista de Chimie, 2019-09-15)

  Cyclodextrins (CD) are macrocyclic biopolymers with potential applications in the delivery of small and macro-molecular therapeutic agents. Despite the potent host-guest inclusion property, their inherent lack of cellular ...
• Beneficial effects of Camelina sativa oil on behavioural (memory, anxiety, depression and social-related) manifestations and oxidative stress parameters in a mice model of irritable bowel syndrome 

  Cojocariu, Roxana; Balmuș, Ioana-Miruna; Lefter, Radu; Hrițcu, Luminița-Diana; Ababei, Daniela-Carmen; Ciobîcă, Alin-Stelian; Copaci, Simona; Copolovici, Lucian; Copolovici, Dana; Jurcoane, Ștefana (University of Bucharest, 2020-04-10)

  Irritable bowel syndrome (IBS) is a common chronic functional gastrointestinal impairment, which includes also a variety of psychological and psychiatric comorbidities. The oxidative stress was earlier reported as ...
• Oxytocin Differentiated Effects According to the Administration Route in a Prenatal Valproic Acid-Induced Rat Model of Autism 

  Lefter, Radu; Ciobîcă, Alin-Stelian; Antioch, Iulia; Ababei, Daniela-Carmen; Hrițcu, Luminița-Diana; Luca, Alina-Costina (MDPI, 2020-05-29)

  The hormone oxytocin (OXT) has already been reported in both human and animal studies for its promising therapeutic potential in autism spectrum disorder (ASD), but the comparative effectiveness of various administration ...
• The Modulation of Oxytocin and Cortisol Levels in Major Depression Disorder and Irritable Bowel Syndrome 

  Hrițcu, Luminița-Diana; Dumitru, Ilie-Ovidiu; Pădurariu, Manuela; Ciobîcă, Alin-Stelian; Spătaru, Mihaela-Claudia; Spătaru, Constantin; Ștefănescu, Gabriela; Ștefănescu, Cristinel; Grecu Gabos, Cristian (Revista de Chimie, 2020-02-07)

  There is a progressive trend in the current literature in understanding the central effects of oxytocin, which besides its classical roles in parturition and lactation, seems to exert some facilitatory effects in most of ...
• Clinical Biochemistry of Cushing Syndrome in Dogs 

  Boghian, Vasile (Revista de Chimie, 2020-04-03)

  The aim of the study is to determine clinical and paraclinical elements useful in the diagnosis of hyperadrenocorticism, given that the symptoms are varied and often similar to dermatitis or liver disease. Clinical signs ...
• Short-term heart-rate variability in healthy small and medium-sized dogs over a five-minute measuring period 

  Baisan, Radu-Andrei; Condurachi, Eusebiu-Ionuț; Vulpe, Vasile (Sciendo, 2020-02-14)

  Introduction: Five-minute heart-rate variability (HRV) measurement is a useful tool for assessing the autonomic nervoussystem (ANS) balance in humans, but there are no studies on healthy dogs. The aim of the study was, ...
• Pestivirus spillover effect: molecular detection of bovine viral diarrhea virus in domestic and feral pigs 

  Aniță, Dragoș-Constantin; Popa, Emilia; Aniță, Adriana-Elena; Ludu Oșlobanu, Luanda-Elena; Savuța, Gheorghe (Colégio Brasileiro de Patologia Animal (CBPA), 2020-08-10)

  Pestivirus infections are important in the livestock industries, with infection occurring in cattle, sheep and pigs. The Pestivirus genus of the family Flaviviridae, includes four recognized species: bovine viral diarrhea ...
• Improvement of the Corrosion Resistance of Biomedical Zr-Ti Alloys Using a Thermal Oxidation Treatment 

  Izquierdo, Javier; Mareci, Daniel; Bolat, Georgiana; Santana, Juan J.; Rodríguez Raposo, Raquel; Fernández Mérida, Luis C.; Burtan, Liviu-Cătălin; Trincă, Lucia-Carmen; Souto, Ricardo M. (MDPI, 2020-01-22)

  Binary Zr-Ti alloys spontaneously develop a tenacious and compact oxide layer when their fresh surface is exposed either to air or to aqueous environments. Electrochemical impedance spectroscopy (EIS) analysis of Zr-45Ti, ...
• Invasive Scedosporium spp. and Lomentospora prolificans infections in pediatric patients: Analysis of 55 cases from FungiScope® and the literature 

  Seidel, Danila; Hassler, Angela; Salmantón García, Jon; Koehler, Philipp; Mellinghoff, Sibylle C.; Carlesse, Fabianne; Cheng, Matthew P.; Falces Romero, Iker; Herbrecht, Raoul; Jover Sáenz, Alfredo; Klimko, Nikolai; Mareș, Mihai; Lass Flörl, Cornelia; Soler Palacín, Pere; Wisplinghoff, Hilmar; Cornely, Oliver A.; Pana, Zoi; Lehrnbecher, Thomas (Elsevier, 2020-02-04)

  Objectives Current knowledge on infections caused by Scedosporium spp. and Lomentospora prolificans in children is scarce. We therefore aim to provide an overview of risk groups, clinical manifestation and treatment ...
• Alzheimer’s Disease Pharmacotherapy in Relation to Cholinergic System Involvement 

  Stanciu, Gabriela-Dumitrița; Luca, Andrei; Rusu, Răzvan-Nicolae; Bild, Veronica; Beșchea Chiriac, Sorin-Ioan; Solcan, Carmen; Bild, Walther; Ababei, Daniela-Carmen (MDPI, 2019-12-26)

  Alzheimer’s disease, a major and increasing global health challenge, is an irreversible, progressive form of dementia, associated with an ongoing decline of brain functioning. The etiology of this disease is not completely ...
• Toxicity of Deltamethrin to Zebrafish Gonads Revealed by Cellular Biomarkers 

  Petrovici, Adriana; Strungaru, Ștefan-Adrian; Nicoară, Mircea; Robea, Mădălina-Andreea; Solcan, Carmen; Faggio, Caterina (MDPI, 2020-01-23)

  Deltamethrin is responsible for health and reproduction problems both in mammals and aquatic organisms. In this study, zebrafish adults were exposed for 15 days to 0.25, 0.5, 1, and 2 μg L−1 non-lethal concentrations of ...
• Prenylated phenolics as promising candidates for combination antibacterial therapy: morusin and kuwanon G 

  Aelenei, Petruța; Rîmbu, Cristina-Mihaela; Horhogea, Cristina-Elena; Lobiuc, Andrei; Neagu, Anca-Narcisa; Dunca, Simona-Isabela; Motrescu, Iuliana; Dimitriu, Gabriel; Aprotosoaie, Ana-Clara; Miron, Anca (Elsevier, 2020-08-18)

  Combination of antibiotics with natural products is a promising strategy for potentiating antibiotic activity and overcoming antibiotic resistance. The purpose of the present study was to investigate whether morusin and ...
• Diagnosis of Pneumocystis jirovecii Pneumonia in Pediatric Patients in Serbia, Greece, and Romania. Current Status and Challenges for Collaboration 

  Arsić Arsenijevic, Valentina; Vyzantiadis, Timoleon-Achilleas; Mareș, Mihai; Otasevic, Suzana; Tragiannidis, Athanasios; Janic, Dragana (MDPI, 2020-04-17)

  Pneumocystis jirovecii can cause fatal Pneumocystis pneumonia (PcP). Many children have been exposed to the fungus and are colonized in early age, while some individuals at high risk for fungal infections may develop PcP, ...
• Needles in a haystack: Extremely rare invasive fungal infections reported in FungiScope (R)-Global Registry for Emerging Fungal Infections 

  Salmantón García, Jon; Koehler, Philipp; Anumpa, Kindo; Falces Romero, Iker; García Rodríguez, Julio; Zdeněk, Ráčil; Chen, Sharon C.-A.; Klimko, Nikolai; Desoubeaux, Guillaume; Thompson, George R. III; Benítez Peñuela, Miguel-Ángel; Rodríguez, José-Yesid; Sheppard, Donald C.; Hoenigl, Martin; Le Govic, Yohann; Badali, Hamid; Baddley, John W.; Chander, Jagdish; Ingram, Paul R.; Pakstis, Diana L.; Mellinghoff, Sibylle C.; Atıcı, Serkan; Cesaro, Simone; Chakrabarti, Arunaloke; Dupont, Damien; González, Gloria M.; Hatvani, Lóránt; Herbrecht, Raoul; Klyasova, Galina; Lass Flörl, Cornelia; Mareș, Mihai; Mullane, Kathleen; Vinh, Donald C.; Wisplinghoff, Hilmar; Lackner, Michaela; Cornely, Oliver A.; Seidel, Danila (Elsevier, 2020-11-01)

  Objectives Emerging invasive fungal infections (IFI) have become a notable challenge. Apart from the more frequently described fusariosis, lomentosporiosis, mucormycosis, scedosporiosis, and certain dematiaceae or yeasts, ...
• How to interpret MICs of antifungal compounds according to the revised clinical breakpoints v. 10.0 European committee on antimicrobial susceptibility testing (EUCAST) 

  Arendrup, Maiken Cavling; Friberg, Nathalie; Mareș, Mihai; Gunnar, Kahlmeter; Meletiadis, J. (Elsevier, 2020-11-09)

  Background EUCAST has revised the definition of the susceptibility category I from ‘Intermediate’ to ‘Susceptible, Increased exposure’. This implies that I can be used where the drug concentration at the site of infection ...
• Antagonistic effects in zebrafish (Danio rerio) behavior and oxidative stress induced by toxic metals and deltamethrin acute exposure 

  Jijie, Roxana; Solcan, Gheorghe; Nicoară, Mircea; Micu, Dragoș; Strungaru, Ștefan-Adrian (Elsevier, 2020-09-16)

  In natural environments, the aquatic organisms are exposed to complex mixtures of chemicals which may originate from natural sources or from anthropogenic activities. In this context, the aim of the study was to assess the ...
• Vitamin C Attenuates Oxidative Stress and Behavioral Abnormalities Triggered by Fipronil and Pyriproxyfen Insecticide Chronic Exposure on Zebrafish Juvenile. 

  Robea, Mădălina-Andreea; Jijie, Roxana; Nicoară, Mircea; Plăvan, Gabriel-Ionuț; Ciobîcă, Alin-Stelian; Solcan, Carmen; Audira, Gilbert; Hsiao, Chung-Der; Strungaru, Ștefan-Adrian (MDPI, 2020-09-15)

  Chronic exposure to synthetic insecticides in the early life of a child can lead to a series of disorders. Several causes as parental age, maternal smoking, birth complications, and exposure to toxins such as insecticides ...
• Novel titanium-apatite hybrid scaffolds with spongy bone-like micro architecture intended for spinal application: In vitro and in vivo study 

  Vlad, Maria-Daniela; Aguado Fernández, Enrique; González Gómez, Sergio; Ivanov, Iuliu-Cristian; Șindilar, Eusebiu-Viorel; Poeată, Ion; Iencean, Andrei-Ștefan; Butnaru, Maria; Avădănei, Elena-Roxana; López López, José (2020-01-11)

  Titanium alloy scaffolds with novel interconnected and non-periodic porous bone-like micro architecture were 3D-printed and filled with hydroxyapatite bioactive matrix. These novel metallic-ceramic hybrid scaffolds were ...

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