Abstract:
Irritable bowel syndrome (IBS) is a common chronic functional gastrointestinal impairment, which
includes also a variety of psychological and psychiatric comorbidities. The oxidative stress was earlier
reported as presenting an important part of the IBS complex pathophysiology. In the present study, we
determined the fatty acids profile and thereafter the effects of Camelina sativa Madalina variety cold pressed
oil in a zymosan-induced model of IBS. We are showing here some facilitatory effects of the Camelina
sativa oil in this context, both on the behavioral and oxidative stress-related actions. Thus, all these results
are suggesting some beneficial effects for the present Camelina sativa oil used in this study on behavioural
(memory, anxiety, depression and social-related) manifestations and oxidative stress parameters in a
zymosan-induced mice model of irritable bowel syndrome. This could be relevant for the connections
between the physiological manifestations in IBS and its depressive-like or anxiolytic-like manifestations.
In conclusion, Camelina sativa oil exerted facilitatory effects on both the behavioral (short memory, as
tested in the Y maze task, anxiety-tested in the elevated plsu maze, depression, as observed in the forced
swimming test and social-dominance test) and oxidative stress-related actions (mainly manifested through
a general increase of the two main antioxidant enzymes determined here: superoxide dismutase and
glutathione peroxidase, as well as a decrease in the lipid peroxidation marker malondialdehyde).
