Water soluble 5 FC complexes, preliminary pharmacological studies

Spulber, Mariana; Miron, Liviu-Dan; Mareș, Mihai; Năstasă, Valentin; Pinteala, Mariana; Fifere, Adrian; Harabagiu, Valeria; Simionescu, Bogdan C.

dc.contributor.author	Spulber, Mariana
dc.contributor.author	Miron, Liviu-Dan
dc.contributor.author	Mareș, Mihai
dc.contributor.author	Năstasă, Valentin
dc.contributor.author	Pinteala, Mariana
dc.contributor.author	Fifere, Adrian
dc.contributor.author	Harabagiu, Valeria
dc.contributor.author	Simionescu, Bogdan C.
dc.date.accessioned	2025-02-21T13:23:20Z
dc.date.available	2025-02-21T13:23:20Z
dc.date.issued	2009-05-30
dc.identifier.citation	Spulber, Mariana, L. Miron, M. Mareș, V. Năstasă, Mariana Pinteală, A. Fifere, Valeria Harabagiu, B. C. Simionescu. 2009. “Water soluble 5 FC complexes, preliminary pharmacological studies”. Journal of Inclusion Phenomena and Macrocyclic Chemistry 65 (3): 431-435. DOI: 10.1007/s10847-009-9594-x	en_US
dc.identifier.issn	0923-0750
dc.identifier.uri	https://link.springer.com/article/10.1007/s10847-009-9594-x
dc.identifier.uri	https://repository.iuls.ro/xmlui/handle/20.500.12811/5159
dc.description.abstract	Flucytosine-b-cyclodextrin and hydroxypropyl b-cyclodextrin water soluble inclusion complex were prepared by freeze drying method in distilled water. The formation of inclusion complex between b-cyclodextrins and flucytosine has been studied and fully described in our previous work [1]. In this paper we are describing the results obtained concerning the antifungal activity of this new compounds. As expected the new inclusion complexes presents a semnificative increase of the antifungal activity, illustrated by the reduction of the minimal inhibitory concentrations for 50 and 90% of the tested strains decreased. Also, the acute toxicity of the flucytosine b cyclodextrin and hydroxypropyl b cyclodextrin complex is smaller comparing with the pure drug, analyzed alone. These results recommend the described conjugates as future promising therapeutic agents.	en_US
dc.language.iso	en	en_US
dc.publisher	Springer Nature Link	en_US
dc.rights	Attribution 4.0 International (CC BY 4.0)
dc.rights.uri	http://creativecommons.org/licenses/by/4.0
dc.subject	Flucytosine	en_US
dc.subject	Antifungal activity	en_US
dc.subject	MIC 50	en_US
dc.subject	MIC 90	en_US
dc.title	Water soluble 5 FC complexes, preliminary pharmacological studies	en_US
dc.type	Article	en_US
dc.author.affiliation	M. Spulber, M. Pinteala, A. Fifere, V. Harabagiu, B. C. Simionescu, Institute of Macromolecular Chemistry Petru Poni, Iasi, Romania
dc.author.affiliation	L. Miron, Department of Parasitology, University of Agricultural Sciences and Veterinary Medicine Ion Ionescu de la Brad, Iasi, Romania
dc.author.affiliation	M. Mares, Department of Mycology-Mycotoxicology, University of Agricultural Sciences and Veterinary Medicine Ion Ionescu de la Brad, Iasi, Romania
dc.author.affiliation	V. Nastasa, Department of Pharmacology, University of Agricultural Sciences and Veterinary Medicine Ion Ionescu de la Brad, Iasi, Romania
dc.publicationName	Journal of Inclusion Phenomena and Macrocyclic Chemistry
dc.volume	65
dc.issue	3
dc.publicationDate	2009
dc.startingPage	431
dc.endingPage	435
dc.identifier.eissn	1573-1111
dc.identifier.doi	10.1007/s10847-009-9594-x