Water soluble 5 FC complexes, preliminary pharmacological studies

Abstract

Flucytosine-b-cyclodextrin and hydroxypropyl b-cyclodextrin water soluble inclusion complex were prepared by freeze drying method in distilled water. The formation of inclusion complex between b-cyclodextrins and flucytosine has been studied and fully described in our previous work [1]. In this paper we are describing the results obtained concerning the antifungal activity of this new compounds. As expected the new inclusion complexes presents a semnificative increase of the antifungal activity, illustrated by the reduction of the minimal inhibitory concentrations for 50 and 90% of the tested strains decreased. Also, the acute toxicity of the flucytosine b cyclodextrin and hydroxypropyl b cyclodextrin complex is smaller comparing with the pure drug, analyzed alone. These results recommend the described conjugates as future promising therapeutic agents.