Antioxidant molecule useful in the stabilization of nanoparticles in water suspension

Abstract

The preparation of antioxidant-coated magnetic nanoparticles (MNPs) has been studied to improve their biocompatibility, i.e. reducing negative side effects. The theoretical study was focused on the interaction of gallic acid (GA) with ionic iron at the surface of nanoparticles that increased reactivity and favors the uniform dispersion in water of magnetic nanoparticles and the interaction with other molecules of biomedical interest. Experimentally, we worked with an optimal method of coating the MNP with GA at 80°C which led to fine granulation highlighted by TEM, preservation of good crystallinity, proven by XRD as well as magnetic properties suitable for biomedical applications based on magnetically targeted guidance. The study of nanotoxicity was focused on the fate of MNPs eliminated in the biosphere, so the influence on photosynthesis in seedlings in early ontogenetic stages was sought. The small variation, with a positive trend, of the efficiency of photosynthesis was correlated with the balancing of the toxic effects, of ROS generation catalyzed by iron ions from the MNP surface by means of the antioxidant character of GA.