Antibacterial Polysiloxane Polymers and Coatings for Cochlear Implants

Cozma, Vlad; Roșca, Irina; Rădulescu, Luminița; Mârțu, Marius-Cristian; Năstasă, Valentin; Varganici, Cristian-Dragoș; Ursu, Elena-Laura; Doroftei, Florica; Pinteala, Mariana; Racles, Carmen

dc.contributor.author	Cozma, Vlad
dc.contributor.author	Roșca, Irina
dc.contributor.author	Rădulescu, Luminița
dc.contributor.author	Mârțu, Marius-Cristian
dc.contributor.author	Năstasă, Valentin
dc.contributor.author	Varganici, Cristian-Dragoș
dc.contributor.author	Ursu, Elena-Laura
dc.contributor.author	Doroftei, Florica
dc.contributor.author	Pinteala, Mariana
dc.contributor.author	Racles, Carmen
dc.date.accessioned	2023-06-23T11:24:31Z
dc.date.available	2023-06-23T11:24:31Z
dc.date.issued	2021-08-12
dc.identifier.citation	Cozma, Vlad, Irina Rosca, Luminita Radulescu, Cristian Martu, Valentin Nastasa, Cristian-Dragos Varganici, Elena-Laura Ursu, Florica Doroftei, Mariana Pinteala, and Carmen Racles. 2021. "Antibacterial Polysiloxane Polymers and Coatings for Cochlear Implants" Molecules 26, no. 16: 4892. https://doi.org/10.3390/molecules26164892	en_US
dc.identifier.uri	https://www.mdpi.com/1420-3049/26/16/4892
dc.identifier.uri	https://repository.iuls.ro/xmlui/handle/20.500.12811/3303
dc.description.abstract	Within this study, new materials were synthesized and characterized based on polysiloxane modified with different ratios of N-acetyl-l-cysteine (NAC) and crosslinked via UV-assisted thiol-ene addition, in order to obtain efficient membranes able to resist bacterial adherence and biofilm formation. These membranes were subjected to in vitro testing for microbial adherence against S. pneumoniae using standardized tests. WISTAR rats were implanted for 4 weeks with crosslinked siloxane samples without and with NAC. A set of physical characterization methods was employed to assess the chemical structure and morphological aspects of the new synthetized materials before and after contact with the microbiological medium.	en_US
dc.language.iso	en	en_US
dc.publisher	MDPI	en_US
dc.rights	CC BY 4.0
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/
dc.subject	Streptococcus pneumoniae	en_US
dc.subject	N-acetyl-l-cysteine	en_US
dc.subject	antibacterial	en_US
dc.title	Antibacterial Polysiloxane Polymers and Coatings for Cochlear Implants	en_US
dc.type	Article	en_US
dc.author.affiliation	Vlad Cozma, Luminita Radulescu, Cristian Martu, Department of Otorhinolaryngology, Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania
dc.author.affiliation	Irina Rosca, Cristian-Dragos Varganici , Elena-Laura Ursu, Florica Doroftei, Mariana Pinteala, Centre of Advanced Research in Bionanoconjugates and Biopolymers, “Petru Poni” Institute of Macromolecular Chemistry, 41A Grigore Ghica Voda Alley, 700487 Iasi, Romania
dc.author.affiliation	Valentin Nastasa, Laboratory of Antimicrobial Chemotherapy, Faculty of Veterinary Medicine, “Ion Ionescu de la Brad” University of Life Sciences, 8 Sadoveanu Alley, 700489 Iasi, Romania
dc.author.affiliation	Carmen Racles, Department of Inorganic Polymers, “Petru Poni” Institute of Macromolecular Chemistry, 41A Grigore Ghica Voda Alley, 700487 Iasi, Romania
dc.publicationName	Molecules
dc.volume	26
dc.issue	26
dc.publicationDate	2021
dc.identifier.eissn	1420-3049
dc.identifier.doi	https://doi.org/10.3390/molecules26164892