Abstract:
Ti-based alloys are widely used in medical applications. When implant devices are used
to reconstruct disordered bone, prevent bone resorption and enhance good bone remodeling, the
Young’s modulus of implants should be close to that of the bone. To satisfy this requirement, many
titanium alloys with different biocompatible elements (Zr, Ta, Mo, Si etc.) interact well with adjacent
bone tissues, promoting an adequate osseointegration. Four new different alloys were obtained and
investigated regarding their microstructure, mechanical, chemical and biological behavior (in vitro
and in vivo evaluation), as follows: Ti20Mo7Zr15Ta, Ti20Mo7Zr15Ta0.5Si, Ti20Mo7Zr15Ta0.75Si and
Ti20Mo7Zr15TaSi. 60 days after implantation, both in control and experimental rabbits, at the level of
implantation gap and into the periimplant area were found the mesenchymal stem cells which differentiate into osteoblasts, then osteocytes and osteoclasts which are involved in the new bone synthesis and remodeling, the periimplant fibrous capsule being continued by newly spongy bone tissue, showing a good osseointegration of alloys. A 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay confirmed the in vitro cytocompatibility of the prepared alloys.
