Research regarding effect of monosodium glutamate on health of laboratory mice

Abstract

Utilization of food additives represents a technique which is more and more present in modern food industry but this one doesn’t have always favourable effects on human organism but on contrary. The study carried out by us aimed to present the impact of one of the most controversial food additives, monosodium glutamate, on organism of laboratory mice and implicit on human organism. Research were carried out on three mice batches, each with 10 individuals, from which one was the control batch LM and two experimental batches LE1 and LE2. Mice from LM received specific nourishment and the animals belonging to the other two batches received besides that specific food different doses of monosodium glutamate, respectively 3% at batch LE1 and 5% for batch LE2. Experimental mice have enjoyed water at their discretion during the whole research period. Research took place during a period of 28 days. In the whole period has been monitored feed consumption, dynamic of corporal mass, and at the end were gathered blood samples for study of some haematological indexes and some parameters connected with blood biochemistry. At the end of the study we observed that MSG induced higher corporal mass gains with 38.4–59.4% at mice from experimental batches face to the ones from control batch, and feed consumption was higher with 7.5–13.8% at experimental batches face to the same reference batch – fact which leads to obesity. Blood analysis show the fact that at animals from experimental batches was recorded a qualitative degradation of blood and very high deviations for the majority of analysed sanguine biochemical parameters. Those aspects show a severe degradation of mice’s health state which formed the experimental batches.