In vivo study of conjugated diminazene aceturate for ichthyophthiriosis of farmed carp

Abstract

The aim of this study was to explore the efficacy of a veterinary drug, Diminazene aceturate (4,4’-(1-Triazene- 1,3-dyil)-bis-(benzenecarboximidamide), in an inclusion complex with β-cyclodextrin as a suitable treatment for parasitic diseases caused by Ichthyophthirius multifiliis in farmed carp. The efficacy was determined by the reduction in the infection intensity. The complexes were prepared by the coevaporation method and were characterized by DSC and FTIR. The selected stoichoimetry for the chosen drug was 1:1. Administration of Diminazene aceturate and complex was carried out by including appropriate doses in animal feed. Our studies suggest that the Diminazene–β-cyclodextrin complex results in a reduction in the infection degree and decrease in the trophont size in the treated fish. The oral treatment of Diminazene aceturate in inclusion complexes may be an alternative to bath treatments in carp farming.