In vitro study of diminazene aceturate complex with Β-Cyclodextrin for ichthyophthirius multifiliis

Abstract

The histophagous ciliate Ichthyophthyrius multifiliis can cause lethality in farmed carp brood (Cyprinus carpio) as well as other representatives. In the present study, an antiparasitic substance (diminazene aceturate) and its complex with a cyclodextrin were tested for its activity against this pathogen in vitro. The purpose of this paper is to highlight the therapeutic potential of diminazene and the enhancement by the β-cyclodextrin. Of these, the complex proved to be more effective (i.e., killed all parasites in a test period of 6-8 hours). Administration in filtered water suggests that these compounds can not be effective in bathing. In view of these findings, we will discuss the potential utility of chemotherapy as a strategy for controlling ciliatosis in farmed fish.