Abstract:
The prevalence of constipation is increasing, one of the causes being the adverse reaction to morphine administration.
Besides drug therapy and alternative remedies (yoga, phytotherapy, acupuncture etc.), another method is a change of
lifestyle, including diet. The aim of this study is to assess the applicability of sericin in food research and development
for special nutritional requirements, including the prevention and treatment of constipation. The study was carried out
comparatively with standard food and bovine lactoferrin, in Wistar rats that were administered morphine in order to
induce constipation. Of the two glycoproteins analyzed, sericin was the most efficient in improving constipation. Feces
with highest deformation, pH, refractometric soluble dry matter were obtained in the group on sericin-supplemented
food. No biochemical changes in urine were noted.