Utilisation of adipose-derived mesenchymal stem cells in the treatment of canine osteoarthritis- case study

Abstract

Adipose-derived mesenchymal stem cells (ADMSCs) have gained attention as a potential treatment for canine osteoarthritis due to their regenerative properties and ability to modulate inflammation. ADMSCs are harvested from adipose (fat) tissue, which is abundant and easily accessible in dogs. The collection procedure is minimally invasive compared to other sources like bone marrow. These stem cells can differentiate into various cell types, including chondrocytes, which are essential for cartilage repair. This ability may help in regenerating damaged cartilage in osteoarthritic joints. ADMSCs secrete various growth factors and cytokines that can reduce inflammation and promote healing, addressing the underlying causes of osteoarthritis rather than just the symptoms. Research has shown promising results in using ADMSCs for treating osteoarthritis in dogs, with improvements in pain, mobility, and overall joint function. ADMSCs can be administered through intra-articular injections directly into the affected joints, allowing for targeted treatment.