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Water soluble sulconazole-b-cyclodextrin complex: physico-chemical characterization and preliminary pharmacological studies

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dc.contributor.author Miron, Liviu-Dan
dc.contributor.author Mareș, Mihai
dc.contributor.author Năstasă, Valentin
dc.contributor.author Spulber, Mariana
dc.contributor.author Fifere, Adrian
dc.contributor.author Pinteala, Mariana
dc.contributor.author Harabagiu, Valeria
dc.contributor.author Simionescu, Bogdan C.
dc.date.accessioned 2025-02-24T07:33:39Z
dc.date.available 2025-02-24T07:33:39Z
dc.date.issued 2008-10-03
dc.identifier.citation Miron, Liviu, M. Mareș, V. Năstasă, Mariana Spulber, A. Fifere, Mariana Pinteală, Valeria Harabagiu, B. C. Simionescu. 2009. “Water soluble sulconazole-b-cyclodextrin complex: physico-chemical characterization and preliminary pharmacological studies”. Journal of Inclusion Phenomena and Macrocyclic Chemistry 63 (1): 159-162. DOI: 10.1007/s10847-008-9501-x en_US
dc.identifier.issn 0923-0750
dc.identifier.uri https://link.springer.com/article/10.1007/s10847-008-9501-x
dc.identifier.uri https://repository.iuls.ro/xmlui/handle/20.500.12811/5160
dc.description.abstract Sulconazole-b-cyclodextrin water soluble inclusion complex was prepared by freeze drying method in distilled water. The formation of inclusion complex between b-cyclodextrin and sulconazole has been studied in a previous work. Preliminary pharmacological studies concerning the antifungal activity showed that the minimal inhibitory concentrations for 90% of the tested strains decreased. Also, the acute toxicity of the sulconazole-bcyclodextrin complex is smaller comparing with the pure drug, analyzed alone. These results recommend the described conjugates as future promising therapeutic agents. en_US
dc.language.iso en en_US
dc.publisher Springer Science+Business Media B.V. en_US
dc.rights Attribution 4.0 International (CC BY 4.0)
dc.rights.uri http://creativecommons.org/licenses/by/4.0
dc.subject Sulconazole nitrate en_US
dc.subject Cyclodextrin en_US
dc.subject Antifungal activity en_US
dc.subject Acute toxicity en_US
dc.subject physico-chemical characterization en_US
dc.subject pharmacological studies en_US
dc.title Water soluble sulconazole-b-cyclodextrin complex: physico-chemical characterization and preliminary pharmacological studies en_US
dc.type Article en_US
dc.author.affiliation M. Spulber, M. Pinteala, A. Fifere, V. Harabagiu, B. C. Simionescu, Institute of Macromolecular Chemistry Petru Poni, Iasi, Romania e-mail: mari_19ian@yahoo.com
dc.author.affiliation L. Miron, Department of Parasitology, University of Agricultural Sciences and Veterinary Medicine Ion Ionescu de la Brad, Iasi, Romania
dc.author.affiliation M. Mares, Department of Mycology-Mycotoxicology, University of Agricultural Sciences and Veterinary Medicine Ion Ionescu de la Brad, Iasi, Romania
dc.author.affiliation V. Nastasa, Department of Pharmacology, University of Agricultural Sciences and Veterinary Medicine Ion Ionescu de la Brad, Iasi, Romania
dc.publicationName Journal of Inclusion Phenomena and Macrocyclic Chemistry
dc.volume 63
dc.issue 1
dc.publicationDate 2009
dc.startingPage 159
dc.endingPage 162
dc.identifier.eissn 1573-1111
dc.identifier.doi 10.1007/s10847-008-9501-x


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Attribution 4.0 International (CC BY 4.0) Except where otherwise noted, this item's license is described as Attribution 4.0 International (CC BY 4.0)