Cardiovascular consequences and Covid-19 infection: establish the model

Abstract

Recent studies have highlighted that the risks for developing cardiovascular alterations are significantly increased in patients who previously suffered from Covid-19. This study aims at determining the functional and structural long-term effects of Covid-19 disease on the cardiovascular system using a specific and original humanized mouse model recapitulating the endogenous cardiovascular expression of the SARS-CoV-2 main receptor ACE2 (Angiotensin Converting Enzyme 2). We will focus on studying the systemic and pulmonary vessels and the cardiac tissue to understand how SARS-CoV-2 infection leads to cardiac and vascular tissue remodelling and function alteration.