dc.contributor.author |
Vasincu, Alexandru |
|
dc.contributor.author |
Rusu, Răzvan-Nicolae |
|
dc.contributor.author |
Ababei, Daniela-Carmen |
|
dc.contributor.author |
Larion, Mădălina |
|
dc.contributor.author |
Bild, Walther |
|
dc.contributor.author |
Stanciu, Gabriela-Dumitrița |
|
dc.contributor.author |
Solcan, Carmen |
|
dc.contributor.author |
Bild, Veronica |
|
dc.date.accessioned |
2023-04-26T06:18:09Z |
|
dc.date.available |
2023-04-26T06:18:09Z |
|
dc.date.issued |
2022-03-14 |
|
dc.identifier.citation |
Vasincu, Alexandru, Răzvan-Nicolae Rusu, Daniela-Carmen Ababei, Mădălina Larion, Walther Bild, Gabriela Dumitrița Stanciu, Carmen Solcan, and Veronica Bild. 2022. "Endocannabinoid Modulation in Neurodegenerative Diseases: In Pursuit of Certainty" Biology 11, no. 3: 440. https://doi.org/10.3390/biology11030440. |
en_US |
dc.identifier.uri |
https://www.mdpi.com/2079-7737/11/3/440 |
|
dc.identifier.uri |
https://repository.iuls.ro/xmlui/handle/20.500.12811/3214 |
|
dc.description.abstract |
Neurodegenerative diseases are an increasing cause of global morbidity and mortality. They occur in the central nervous system (CNS) and lead to functional and mental impairment due to loss of neurons. Recent evidence highlights the link between neurodegenerative and inflammatory diseases of the CNS. These are typically associated with several neurological disorders. These diseases have fundamental differences regarding their underlying physiology and clinical manifestations, although there are aspects that overlap. The endocannabinoid system (ECS) is comprised of receptors (type-1 (CB1R) and type-2 (CB2R) cannabinoid-receptors, as well as transient receptor potential vanilloid 1 (TRPV1)), endogenous ligands and enzymes that synthesize and degrade endocannabinoids (ECBs). Recent studies revealed the involvement of the ECS in different pathological aspects of these neurodegenerative disorders. The present review will explore the roles of cannabinoid receptors (CBRs) and pharmacological agents that modulate CBRs or ECS activity with reference to Alzheimer’s Disease (AD), Parkinson’s Disease (PD), Huntington’s Disease (HD) and multiple sclerosis (MS). |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
MDPI |
en_US |
dc.rights |
CC BY 4.0 |
|
dc.rights.uri |
https://creativecommons.org/licenses/by/4.0/ |
|
dc.subject |
multiple sclerosis |
en_US |
dc.subject |
Huntington’s |
en_US |
dc.subject |
endocannabinoid system |
en_US |
dc.subject |
neurodegenerative |
en_US |
dc.subject |
Alzheimer’s |
en_US |
dc.subject |
Parkinson’s |
en_US |
dc.subject |
phytocannabinoids |
en_US |
dc.title |
Endocannabinoid Modulation in Neurodegenerative Diseases: In Pursuit of Certainty |
en_US |
dc.type |
Article |
en_US |
dc.author.affiliation |
Alexandru Vasincu, Răzvan-Nicolae Rusu, Daniela-Carmen Ababei,Veronica Bild, Department of Pharmacodynamics and Clinical Pharmacy, “Grigore T Popa” University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania |
|
dc.author.affiliation |
Mădălina Larion, Department of Anaesthesiology Intensive Therapy, Regional Institute of Gastroenterology and Hepatology “Prof. Dr. Octavian Fodor”, 19 Croitorilor Street, 400162 Cluj-Napoca, Romania |
|
dc.author.affiliation |
Mădălina Larion, Department of Anaesthetics, Midland Regional Hospital, Longford Road, Mullingar, N91 NA43 Co. Westmeath, Ireland |
|
dc.author.affiliation |
Walther Bild, Department of Physiology, “Grigore T Popa” University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania |
|
dc.author.affiliation |
Walther Bild, Veronica Bild, Center of Biomedical Research of the Romanian Academy, 700506 Iasi, Romania |
|
dc.author.affiliation |
Gabriela Dumitrița Stanciu,Veronica Bild, Center for Advanced Research and Development in Experimental Medicine (CEMEX), “Grigore T. Popa” University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania |
|
dc.author.affiliation |
Carmen Solcan, Preclinics Department, “Ion Ionescu de la Brad” University of Life Sciences, 8 M. Sadoveanu Alley, 700489 Iasi, Romania |
|
dc.publicationName |
Biology |
|
dc.volume |
11 |
|
dc.issue |
3 |
|
dc.publicationDate |
2022 |
|
dc.identifier.eissn |
2079-7737 |
|
dc.identifier.doi |
https://doi.org/10.3390/biology11030440 |
|