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Reviewing the Potential Therapeutic Approaches Targeting the Modulation of Gastrointestinal Microflora in Schizophrenia

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dc.contributor.author Niță, Ilinca-Bianca
dc.contributor.author Ilie, Ovidiu-Dumitru
dc.contributor.author Ciobîcă, Alin-Stelian
dc.contributor.author Hrițcu, Luminița-Diana
dc.contributor.author Dobrin, Irina
dc.contributor.author Doroftei, Bogdan
dc.contributor.author Dobrin, Romeo-Petru
dc.date.accessioned 2023-04-24T11:26:15Z
dc.date.available 2023-04-24T11:26:15Z
dc.date.issued 2022-12-17
dc.identifier.citation Nita, Ilinca-Bianca, Ovidiu-Dumitru Ilie, Alin Ciobica, Luminita-Diana Hritcu, Irina Dobrin, Bogdan Doroftei, and Romeo Dobrin. 2022. "Reviewing the Potential Therapeutic Approaches Targeting the Modulation of Gastrointestinal Microflora in Schizophrenia" International Journal of Molecular Sciences 23, no. 24: 16129. https://doi.org/10.3390/ijms232416129. en_US
dc.identifier.uri https://www.mdpi.com/1422-0067/23/24/16129
dc.identifier.uri https://repository.iuls.ro/xmlui/handle/20.500.12811/3202
dc.description.abstract Schizophrenia (SCZ) is a severe brain disorder characterized by an intriguing clinical panel that has begun to gain interest due to its particular phenotype. Having considered the role of gut microflora in psychiatry, the latest discoveries might offer further insight into the underlying mechanisms. Thus, we aimed to offer an updated overview of the therapeutic potential of microorganism-derived supplements alongside dedicated protocols that target the re-establishment of the host’s eubiosis. Based on combinations of specific keywords, we performed searches in four databases (PubMed/Medline, ISI Web of Knowledge, Scopus, and ScienceDirect) for the established interval (2018–2022) and identified twenty two eligible cases, restricted only to human patients’ experiences. Up until the writing of this manuscript, it has been revealed that the administration of specific lactic acid bacteria strains (Lactobacillus and Bifidobacterium), or those combined with vitamin D and selenium, maintain the integrity of the gut flora, preventing antagonistic effects including inflammation, antipsychotic-related body weight gain (olanzapine) and other metabolic dysfunctionalities. However, there are multiple antipsychotics that exert a potent effect upon gut flora, influencing a plethora of pathways and creating a dysbalance ratio between beneficial and opportunistic pathogens. Risperidone, amisulpride, and clozapine are just a few examples, but the current literature is unfortunately inconsistent and reported data is contradictory, which is why we support additional studies in this context. Moreover, we further argue the utility of studying how distinct controlled substances influence microbial communities, considering that ketamine is proved to alleviate depressive-like behavior as opposed to amphetamine and phencyclidine, which are known substances to trigger SCZ-like symptoms in experimental models. Probiotics may be regarded as the most consequential vehicle through which the gut flora can be successfully influenced, in adequate doses exerting a beneficial role as an alternative approach to alleviate SCZ symptoms. en_US
dc.language.iso en en_US
dc.publisher MDPI en_US
dc.rights https://creativecommons.org/licenses/by/4.0/
dc.rights.uri CC BY 4.0
dc.subject microbial transfer therapy en_US
dc.subject fecal microbiota transplantation en_US
dc.subject schizophrenia en_US
dc.subject synbiotics en_US
dc.subject prebiotics en_US
dc.subject probiotics en_US
dc.subject gut microflora en_US
dc.title Reviewing the Potential Therapeutic Approaches Targeting the Modulation of Gastrointestinal Microflora in Schizophrenia en_US
dc.type Article en_US
dc.author.affiliation Ilinca-Bianca Nita, Irina Dobri, Romeo Dobrin, Department of Medicine III, Faculty of Medicine, University of Medicine and Pharmacy “Grigore T. Popa”, University Street, no 16, 700115 Iasi, Romania
dc.author.affiliation Ovidiu-Dumitru Ilie, Alin Ciobica, Department of Biology, Faculty of Biology, “Alexandru Ioan Cuza” University, Carol I Avenue, no 20A, 700505 Iasi, Romania
dc.author.affiliation Luminita-Diana Hritcu, Internal Medicine Clinic, Faculty of Veterinary Medicine, University of Life Sciences “Ion Ionescu de la Brad”, Mihail Sadoveanu Street, no 3, 700490 Iasi, Romania
dc.author.affiliation Irina Dobrin, Romeo Dobrin, Institute of Psychiatry “Socola”, Bucium Street, no 36, 700282 Iasi, Romania
dc.author.affiliation Bogdan Doroftei, Department of Medicine VIII, Faculty of Medicine, University of Medicine and Pharmacy “Grigore T. Popa”, University Street, no 16, 700115 Iasi, Romania
dc.publicationName International Journal of Molecular Sciences
dc.volume 23
dc.issue 24
dc.publicationDate 2022
dc.identifier.eissn 1422-0067
dc.identifier.doi https://doi.org/10.3390/ijms232416129


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