dc.contributor.author |
Niță, Ilinca-Bianca |
|
dc.contributor.author |
Ilie, Ovidiu-Dumitru |
|
dc.contributor.author |
Ciobîcă, Alin-Stelian |
|
dc.contributor.author |
Hrițcu, Luminița-Diana |
|
dc.contributor.author |
Dobrin, Irina |
|
dc.contributor.author |
Doroftei, Bogdan |
|
dc.contributor.author |
Dobrin, Romeo-Petru |
|
dc.date.accessioned |
2023-04-24T11:26:15Z |
|
dc.date.available |
2023-04-24T11:26:15Z |
|
dc.date.issued |
2022-12-17 |
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dc.identifier.citation |
Nita, Ilinca-Bianca, Ovidiu-Dumitru Ilie, Alin Ciobica, Luminita-Diana Hritcu, Irina Dobrin, Bogdan Doroftei, and Romeo Dobrin. 2022. "Reviewing the Potential Therapeutic Approaches Targeting the Modulation of Gastrointestinal Microflora in Schizophrenia" International Journal of Molecular Sciences 23, no. 24: 16129. https://doi.org/10.3390/ijms232416129. |
en_US |
dc.identifier.uri |
https://www.mdpi.com/1422-0067/23/24/16129 |
|
dc.identifier.uri |
https://repository.iuls.ro/xmlui/handle/20.500.12811/3202 |
|
dc.description.abstract |
Schizophrenia (SCZ) is a severe brain disorder characterized by an intriguing clinical panel that has begun to gain interest due to its particular phenotype. Having considered the role of gut microflora in psychiatry, the latest discoveries might offer further insight into the underlying mechanisms. Thus, we aimed to offer an updated overview of the therapeutic potential of microorganism-derived supplements alongside dedicated protocols that target the re-establishment of the host’s eubiosis. Based on combinations of specific keywords, we performed searches in four databases (PubMed/Medline, ISI Web of Knowledge, Scopus, and ScienceDirect) for the established interval (2018–2022) and identified twenty two eligible cases, restricted only to human patients’ experiences. Up until the writing of this manuscript, it has been revealed that the administration of specific lactic acid bacteria strains (Lactobacillus and Bifidobacterium), or those combined with vitamin D and selenium, maintain the integrity of the gut flora, preventing antagonistic effects including inflammation, antipsychotic-related body weight gain (olanzapine) and other metabolic dysfunctionalities. However, there are multiple antipsychotics that exert a potent effect upon gut flora, influencing a plethora of pathways and creating a dysbalance ratio between beneficial and opportunistic pathogens. Risperidone, amisulpride, and clozapine are just a few examples, but the current literature is unfortunately inconsistent and reported data is contradictory, which is why we support additional studies in this context. Moreover, we further argue the utility of studying how distinct controlled substances influence microbial communities, considering that ketamine is proved to alleviate depressive-like behavior as opposed to amphetamine and phencyclidine, which are known substances to trigger SCZ-like symptoms in experimental models. Probiotics may be regarded as the most consequential vehicle through which the gut flora can be successfully influenced, in adequate doses exerting a beneficial role as an alternative approach to alleviate SCZ symptoms. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
MDPI |
en_US |
dc.rights |
https://creativecommons.org/licenses/by/4.0/ |
|
dc.rights.uri |
CC BY 4.0 |
|
dc.subject |
microbial transfer therapy |
en_US |
dc.subject |
fecal microbiota transplantation |
en_US |
dc.subject |
schizophrenia |
en_US |
dc.subject |
synbiotics |
en_US |
dc.subject |
prebiotics |
en_US |
dc.subject |
probiotics |
en_US |
dc.subject |
gut microflora |
en_US |
dc.title |
Reviewing the Potential Therapeutic Approaches Targeting the Modulation of Gastrointestinal Microflora in Schizophrenia |
en_US |
dc.type |
Article |
en_US |
dc.author.affiliation |
Ilinca-Bianca Nita, Irina Dobri, Romeo Dobrin, Department of Medicine III, Faculty of Medicine, University of Medicine and Pharmacy “Grigore T. Popa”, University Street, no 16, 700115 Iasi, Romania |
|
dc.author.affiliation |
Ovidiu-Dumitru Ilie, Alin Ciobica, Department of Biology, Faculty of Biology, “Alexandru Ioan Cuza” University, Carol I Avenue, no 20A, 700505 Iasi, Romania |
|
dc.author.affiliation |
Luminita-Diana Hritcu, Internal Medicine Clinic, Faculty of Veterinary Medicine, University of Life Sciences “Ion Ionescu de la Brad”, Mihail Sadoveanu Street, no 3, 700490 Iasi, Romania |
|
dc.author.affiliation |
Irina Dobrin, Romeo Dobrin, Institute of Psychiatry “Socola”, Bucium Street, no 36, 700282 Iasi, Romania |
|
dc.author.affiliation |
Bogdan Doroftei, Department of Medicine VIII, Faculty of Medicine, University of Medicine and Pharmacy “Grigore T. Popa”, University Street, no 16, 700115 Iasi, Romania |
|
dc.publicationName |
International Journal of Molecular Sciences |
|
dc.volume |
23 |
|
dc.issue |
24 |
|
dc.publicationDate |
2022 |
|
dc.identifier.eissn |
1422-0067 |
|
dc.identifier.doi |
https://doi.org/10.3390/ijms232416129 |
|