The increase in the photodynamic potential of dacarbazine as a result of Ph dependence

Abstract

Photostimulated chemotherapy (PSChT) is a relatively new therapeutic method whose principle is based on increasing the therapeutic index of certain cytostatics as a result of their interaction with optical radiation. For a particular chemotherapeutic agent to be effective in PSChT-type applications, it must fulfill several conditions, the most important of which is to have a positive photodynamic potential that consists in the resonant transfer of energy between the irradiation source and its molecule. In this study, Dacarbazine (DTIC) was used as the photosensitizing agent, and a highpressure mercury lamp was used as the irradiating agent. Preclinical studies in BL / 6 inbred mice carrying B16 murine melanoma and spectrophotometric determinations were performed to identify whether the DTIC-PSChT method enhances the efficacy of chemotherapy.