Mouse models and Sars-Cov-2

Abstract

Since December 2019, a novel coronavirus SARS-CoV-2 has emerged and rapidly spread throughout the world, resulting in a global public health emergency. COVID-19 is causing a major once-in-a century global pandemic. The emergences of coronaviruses have caused a serious global public health problem because their infection in humans caused the severe acute respiratory disease and deaths. Much more serious than SARS-CoV in 2002, the current SARS-CoV-2 infection has been spreading to more than 213 countries, areas or territories and causing more than 31 million cases and 962,518 deaths (update september 2020). Intensive research efforts have focused on increasing our understanding of viral biology of SARS-CoV-2, improving antiviral therapy and vaccination strategies. The lack of vaccine and antivirals has brought an urgent need for an animal model. The animal models are important for both the fundamental research and drug discovery of coronavirus.