Pharmacoclinical observations on the evolution of cardiovascular variables and acid-base balance under the combination of acepromazine-morphine in dog

Abstract

The paper investigated the intensity of the main cardiorespiratory values, which were modified in the case of acepromazine-morphine anaesthesia in dog. The study was carried out on 16 dogs, in which the tension of blood gases was checked. The level of sedations was measured by taking into consideration the awareness degree and how long they were able to keep their lateral position. The sedation degree was present at a rate of 23% after using acepromazine (0.4 kg/kc; level 1), 89% after injecting intravenously the morphine (0.02 mg/kc; level 2) and of 100%, after 0.2 mg/kc morphine, which did not produce significant statistical modifications on the values of hemodynamic function. Our experiments have shown that the dose interval, comprised between 0.2 and 0.5 mg/kc of acepromazine, combined with 0.02-0.2 mg/kc morphine, proved to have satisfying effect.