Abstract:
The purpose of the study was
to assess the effect of selenium
supplementation on serum amylase, lactate
dehydrogenase (LDH) and alkaline
phosphatase (ALP) activities in rats, during
subacute exposure to toxic doses of
cadmium or lead through the drinking
water. The experimental groups (n=6) were:
Control, Se (Se+4: 0,2 mg/l), Cd (Cd+2: 150
mg/l), Pb (Pb+2: 300 mg/l), Cd+Se (Cd+2:
150 mg/l; Se+4: 0,2 mg/l) and Pb+Se (Pb+2:
300 mg/l; Se+4: 0,2 mg/l). The animals were
sacrificed after 56 days. Amylase, LDH and
ALP activities were determined from serum.
Se and Pb treatments caused an increase in
amylase and LDH activities, when
compared to Control group while Cd caused
an increase in amylase activity and a
decrease in LDH and ALP activities. Cd+Se
caused a decrease in amylase activity and an
increase in LDH activity, when compared to
Cd. Pb+Se caused a decrease in amylase
activity in comparison to lead. Selenium
supplementation alleviated cadmium or lead
induced changes in serum amylase activity.
Selenium, coadministered with cadmium,
caused a marked increase in serum LDH
activity, when compared to cadmium alone
or Control group while practically it had no
effect on lead induced changes in LDH
activity. Cadmium and lead induced
disturbances in serum ALP activity were not
influenced by selenium supplementation.
