Deoxyribonucleic acid interactions specific to biochemical injury induced by some carcinogenic xenobiotics

Abstract

At the origin of the neoplastic processes in which deoxyribonucleic acid is involved, one can mention as trigger factors a great number of xenobiotics which are present in the air, feedstuffs, foodstuffs and water having harmful effects on animals and humans. Xenobiotics of various sources : chemical (organic and inorganic compounds), physical (ionizing radiations, UV radiation) and biological (oncoviruses) can become carcinogenic agents.Submitted as a review the aim of this paper is to give data on the molecular mechanisms inducing biochemical injuries as a consequence of the interaction of deoxyribonucleic acid (DNA) with various chemical compounds. The interactions of DNA with the following organic compunds are discussed : aflatoxins (AF), polycyclic aromatic hydrocarbons (PAH), aromatic amines and the following inorganic compounds : some metal ions (Mn+) with toxicogene potential; nitrates (NO3 and nitrites (NO These interactions are of interest for comparative medicine due to their pathobiochemical and pathophysiological aspects. All the above mentioned adducts are frequently discussed in pathology being at the origin of the biochemical injury which can evolve to a carcinogen process. Initially the nuclear DNA is damaged and further on the cell. If the pathological process develops the result is the formation and growth of a neoplasm.