Metabolical changes in HBV/ HIV coinfections

Abstract

The aim of this study was to evaluate the main metabolic changes in the case of hepatitis B virus (HBV) / human imunodeficiency virus (HIV) coinfection. A retrospective study, on 482 HIV infected patients was assesed, at Iasi Regional HIV-AIDS Center Iasi, between 2000-2014. Subjects were divided into 2 groups, according to the presence or absence of HBV coinfection. HIV prevalence was higher in the 20-29 years aged group (86.5%), parenteral routes being the predominant mode of HIV transmission (61.5% vs 58.5%). Mean ALT levels were significantly higher (p<0.001) in the HBV group (49.92 IU/L vs 32.93 IU/L). Average total cholesterol levels were significantly higher (p<0.001) in the HBV group( 182.58 vs 167.59 mg%). The average levels of serum triglycerides in the HBV group were significantly lower (p<0.001) than those recorded in the nonHBV group (130.72 vs. 164.59 mg%). Dyslipidemia was common in the HIV/HBV coinfected group (107 vs. 82). Hepatitis B virus infection induced a 2-fold higher relative risk for the occurence of hepatic cytolysis syndrome .