Ameliorative effect of cinnamon aqueous extract against hypercholesterolemia induced hepatic alterations in rats

Abstract

This study was done on four groups of male wistar rats. Control group, cinnamon aqueous group which fed on 200 mg/kg/day cinnamon aqueous extract orally, control positive group which was fed on a high cholesterol diet and treated group and was fed a high cholesterol diet and given cinnamon aqueous extract orally at 200 mg/kg/day for two months to evaluate the ameliorative effect of cinnamon aqueous extract on the alterations in liver induced by hypercholesterolemia. The histopathological findings showed vacuolar degeneration in some areas of the hepatic tissues. Diffuse fatty degeneration was noticed in most of the hepatocytes. Thickening in the CT surround the central and portal vein. The hepatic cells showed faint positive immunostaining reaction forKi67. In the treated group regeneration was noticed in most of the hepatocytes. The cells showed cytoplasmic degranulation especially the cells in the triad areas. Proliferation of the vonkupher cells was noticed. The hepatocytes showed positive immunostaining for Ki67 which indicate cell viability.Also theaddition of cinnamon aqueous extract adjusts the highest level of cholesterol, triglycerides, and low-density lipoprotein.