Abstract:
Experimental research
followed by clinical studies have
demonstrated the existence of several types
of pain, thus the pain classification
according to the mediation has widely
extended. In addition, the study of the
interactions with pharmacodynamic
mechanism expanded very much during the
last years; therefore in the new theories
appear significant changes concerning
synergism, addition and subadditivity in
binary combinations. The investigations in
this paper were aimed the demonstration of
the antinociceptive of some drugs with
anticonvulsant action and the analysis of
their binary combinations with tramadol,
using isobolar analysis. As model of
nociception has been used the test of
abdominal constrictive response in mouse
induced by Zymosan A. the test substances
were administered orally alone or in fixed
proportion combinations. The data obtained
were subjected to isobolar analysis.
According to the statistical analysis the
following have been observed: the binary
combination tramadol-VA has proven to be
synergistic (Zmix < Zadd, f = 0,5, p1 = 677,
Tc =3.936, Tt = 3,529, c = 12.78, Ft = 4.46,
p < 0.05), while the binary combination
tramadol-CBZ has proven to be borderline
additive (Z mix < Zadd).
