Biochemical evaluation on propolis in experimental STZ diabetic rats

Abstract

Abstract This aim of study was to describe the antidiabetic activity of Propolis on 60 male rat and weighting 200 – 250 gm. the rat were divided into three equal groups of 20 male rats. Group 1: control Normal group (CN).Group 2: diabetic group (DN). Group 3: Propolis treated group orally (60 mg/kg bwt /day) for 50 days (8weeks). Blood samples were collected from all animal groups after 4 & 6 and 8weeks from the onset of treatment and processed directly for determination of Glucose, Urea, creatinine , Uric acid , Albumin , Cholesterol, triglyceride, HDL, LDL concentration in blood serum and activities AST, ALT in addition to MDA, GSH, and SOD activities in RBCs. The obtained results revealed a significant increase in Glucose , urea, creatinine, uric acid, Cholesterol, Trigyycreide, LDL , MDA level AST, ALT activity a marked significant depletion in GSH content and SOD activity in the blood of diabetic rat compared to control. Contrary results obtained in diabetic group (DN) treated with Propolis So, From the obtained results of the present study it could be concluded that administration of citrullus colocynthis to diabetic rat which may improve glucose, kidney function, liver enzyme, lipid profile, antioxidant enzyme.