Degerative aspects observed in seminiferous tubules in quails (Coturnix Japonica) testis after monosodium glutamate administration in feed

Abstract

Sodium glutamate, an amino acid used as a flavor enhancer, is a controversial substance being incriminated in the appearance of obesity in human populations among others. Its administration in animal feed increases weight gain, but side effects such as decreased fertility and degenerative changes in liver and kidney have been observed. To study the effects of monosodium glutamate toxicity on the male reproductive system, one hundred thirty-four Japanese quails (Coturnix japonica) were divided into 4 groups. Monosodium glutamate was admninistrated for 30 days in different concentrations in 3 groups: 10g/kg feed for group I, 30g/kg feed for group II, 50 g/kg feed for group III. For the individuals in group II and III, was observed the reduction in the number of germline and sperm cells compared to the control group, the presence of degenerative Sertoli cells and spermatic cells with pyknotic nuclei, the presence of vacuoles among seminiferous tubule cells. The degenerative, necrotic and inflammatory changes observed demonstrate the toxic effects of glutamate on male reproductive system and on fertility.